What causes the rash in meningococcal Septicaemia?
As this happens, the bacteria rapidly multiply and produce toxins which travel around the body causing damage to blood vessels and organs. As the blood vessels get damaged, blood starts to ‘leak’ into the surrounding tissue, often causing what looks like a ‘rash’ to appear on the skin.
What is the pathogenesis of meningococcal sepsis?
The complex physiology of meningococcal sepsis is largely explained by four basic processes affecting the microvasculature: (1) Increased vascular permeability (2) Pathological vasoconstriction and vasodilatation (3) Loss of thromboresistance and intravascular coagulation (4) Profound myocardial dysfunction.
What is the pathophysiology of meningococcemia?
The fundamental pathologic change in meningococcemia is widespread vascular injury characterized by endothelial necrosis, intraluminal thrombosis, and perivascular hemorrhage. Endotoxin, cytokines, and free radicals damage the vascular endothelium, producing platelet deposition and vasculitis.
Why does meningococcal cause purpura?
Purpura fulminans (PF) is a dreadful and frequent complication of Neisseria meningitidis invasive infection, and is associated with a high mortality rate. This syndrome begins with dermal microvessels thrombosis that rapidly lead to hemorrhagic skin necrosis.
What is sepsis pathophysiology?
The roles of inflammation and coagulation in the pathophysiology of sepsis are described. Sepsis results when an infectious insult triggers a localized inflammatory reaction that then spills over to cause systemic symptoms of fever or hypothermia, tachycardia, tachypnea, and either leukocytosis or leukopenia.
What is meningococcal B Septicaemia?
Meningococcal Septicemia (aka Meningococcemia) Doctors call septicemia (a bloodstream infection) caused by Neisseria meningitidis meningococcal septicemia or meningococcemia. When someone has meningococcal septicemia, the bacteria enter the bloodstream and multiply, damaging the walls of the blood vessels.
What is Purpura and its causes?
Purpura occurs when small blood vessels burst, causing blood to pool under the skin. This can create purple spots on the skin that range in size from small dots to large patches. Purpura spots are generally benign, but may indicate a more serious medical condition, such as a blood clotting disorder.